Biochem/physiol Actions

Primary Targetsterol & fatty acid biosynthesis

General description

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Loftus, T.M., et al. 2000. Science288, 2379.Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Harmful (C)